Enterovirus D68 Antivirals: Past, Present, and Future.

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Abstract

Enterovirus D68 (EV-D68) is an RNA virus that causes respiratory illnesses mainly in children. In severe cases, it can lead to neurological complications such as acute flaccid myelitis (AFM). EV-D68 belongs to the enterovirus genera of the Picornaviridae family, which also includes many other significant human pathogens such as poliovirus, enterovirus A71, and rhinovirus. There are currently no vaccines or antivirals against EV-D68. In this review, we present the current understanding of the link between EV-D68 and AFM, the mechanism of viral replication, and recent progress in developing EV-D68 antivirals by targeting various viral proteins and host factors that are essential for viral replication. The future directions of EV-D68 antiviral drug discovery and the criteria for drugs to reach clinical trials are also discussed.

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Author and article information

Journal

Journal ID (iso-abbrev): ACS Infect Dis

Title: ACS infectious diseases

Publisher: American Chemical Society (ACS)

ISSN (Electronic): 2373-8227

ISSN (Print): 2373-8227

Publication date (Electronic): July 10 2020

Volume: 6

Issue: 7

Affiliations

[1 ] Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States.

Article

DOI: 10.1021/acsinfecdis.0c00120

PubMed ID: 32352280

SO-VID: 35f088a3-05d4-4891-bf64-b8028725b751

History

Keywords: enterovirus D68,acute flaccid myelitis,antiviral

Data availability:

Keywords: enterovirus D68, acute flaccid myelitis, antiviral

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