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Correlation of Nrf2 and HIF-1α in glioblastoma and their relationships to clinicopathologic features and survival.
Xiangjun Ji
1 ,
Handong Wang ,
Jianhong Zhu ,
Yong Tang ,
Yuan Zhou ,
Lin Zhu ,
Chaochao Gao ,
Wei Li ,
Wanchun You ,
Bo Yu ,
Qiuyuan Xia
Dec 2013
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Abstract
Glioblastoma (GB) is the most common, aggressive, and proliferative among all brain tumors. The prognosis of GB is still far from satisfactory currently, thus demanding great modification and enhancement, which may be acquired by the help of the molecular target therapy. Nuclear factor E2-related factor 2 (Nrf2), a pivotal transcriptional factor of cellular responses to oxidative stress, was observed to function remarkably in cancer pathobiology. In the current study, we analyzed the correlation between Nrf2 and Hypoxia-inducible factor-1alpha (HIF-1alpha) in GB, together with their association to the features and survival of clinicopathology.