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      Proinflammatory Cytokines as Pathogenetic Mediators in the Central Nervous System: Brain-Periphery Connections

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          Abstract

          Cytokines can be produced within the brain and are implicated as pathogenetic mediators of pathologies of the central nervous system (CNS). They cause various CNS effects, inducing fever, anorexia, sleepiness and activating the hypothalamus-pituitary-adrenal axis. Centrally administered cytokines cause peripheral effects such as induction of the synthesis of hepatic acute-phase proteins (APP). Some of their effects (e.g. anorexia, APP synthesis, fever) may result from both central and peripheral actions. Some represent feedback mechanisms that inhibit excess cytokine production.

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          Author and article information

          Journal
          NIM
          Neuroimmunomodulation
          10.1159/issn.1021-7401
          Neuroimmunomodulation
          S. Karger AG
          1021-7401
          1423-0216
          1995
          1995
          22 May 1995
          : 2
          : 1
          : 2-15
          Affiliations
          Laboratory of Neuroimmunology, ‘Mario Negri’ Institute for Pharmacological Research, Milano, Italy
          Article
          96828 Neuroimmunomodulation 1995;2:2–15
          10.1159/000096828
          7614256
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 14
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          Review

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