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      Increased Expression of 8-Hydroxydeoxyguanosine in Acquired Cystic Disease of the Kidney

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      S. Karger AG

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          Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues.

           Y Kuchino,  F Mori,  H. Kasai (2015)
          It has been shown previously that deoxyguanosine residues in DNA are hydroxylated at the C-8 position both in vitro and in vivo to produce 8-hydroxydeoxyguanosine (8-OH-dG) by various agents that produce oxygen radicals such as reducing reagents-O2, metal ions-O2, polyphenol-H2O2-Fe3+, asbestos-H2O2 or ionizing radiation. These agents are mostly either mutagenic or carcinogenic; therefore, the formation of 8-OH-dG can also be considered a likely cause of mutation or carcinogenesis by oxygen radicals. It is of interest to know whether the 8-OH-dG residue in DNA is misread during DNA replication. To answer this question, we have examined the effect of the 8-OH-dG residue in DNA on the fidelity of DNA replication using a DNA synthesis system in vitro with Escherichia coli DNA polymerase I (Klenow fragment). The synthetic oligodeoxynucleotides, with or without an 8-OH-dG residue in a specified position, were chemically synthesized and used as templates for DNA synthesis under the conditions of the dideoxy chain termination sequencing method. Surprisingly, in addition to misreading of the 8-OH-dG residue itself, pyrimidines next to the 8-OH-dG residue (G has not yet been tested) were also misread.
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            Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay


              Author and article information

              S. Karger AG
              April 1999
              31 March 1999
              : 81
              : 4
              : 458-459
              Department of Urology, Kidney Center, Tokyo Women’s Medical University School of Medicine, <city>Tokyo</city>, Japan
              45340 Nephron 1999;81:458–459
              © 1999 S. Karger AG, Basel

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              Page count
              Figures: 1, Tables: 1, References: 8, Pages: 2
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/45340
              Letter to the Editor

              Cardiovascular Medicine, Nephrology


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