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      Effect of [4CI- D-Phe 6, Leu 17]VIP on the Inhibition of Pulsatile LH Release by VIP and Related Peptides in the Ovariectomized Rat

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          Abstract

          Pulsatile LH secretion in the ovariectomized (OVX) rat is inhibited by intra-cerebroventricular (icv) infusion of vasoactive intestinal peptide (VIP). VIP, rat growth hormone-releasing hormone (rGRH) and secretin with and without an antagonist to VIP, [4Cl- D-Phe<sup>6</sup>, Leu<sup>17</sup>]VIP (VIPA), were infused icv into OVX rats. Both VIP and rGRH at an infusion rate of 3.5 nmol/h lowered mean LH concentrations and pulse frequency without affecting pulse amplitude, and these effects were blocked by concurrent infusion of VIPA (10.5 nmol/h). Secretin also inhibited pulsatile LH secretion, but was only fully effective at the higher infusion rate of 7 nmol/h. This effect of secretin was also blocked by concurrent infusion of 10.5 nmol/h of VIPA. These results suggest that all three of these peptide hormones inhibit pulsatile LH secretion by an interaction with VIP receptors.

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          Author and article information

          Journal
          Journal ID (publisher-id): NEN
          Journal ID (nlm-ta): Neuroendocrinology
          Journal ID (doi): 10.1159/issn.0028-3835
          Title: Neuroendocrinology
          Publisher: S. Karger AG
          ISSN (Print): 0028-3835
          ISSN (Electronic): 1423-0194
          Publication date Subscription-year: 1992
          Publication date (Print): 1992
          Publication date (Electronic): 07 April 2008
          Volume: 56
          Issue: 5
          Pages: 646-652
          Affiliations
          Department of Physiology, University of Western Ontario, London, Ont., Canada
          Article
          Publisher ID: 126288 Other ID: Neuroendocrinology 1992;56:646–652
          DOI: 10.1159/000126288
          PubMed ID: 1488097
          SO-VID: 360269bd-4d72-4291-aafe-a4fcde2662c1
          Copyright © © 1992 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 26 July 1991
          Date accepted : 04 March 1992
          Page count
          Pages: 7
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Keywords: Rat growth hormone-releasing hormone,Pulsatile LH release,Secretin,Vasoactive intestinal peptide,VIP antagonist,[4Cl-<italic>D</italic>-Phe6, Leu17]VIP
          Data availability:
          ScienceOpen disciplines: Endocrinology & Diabetes, Neurology, Nutrition & Dietetics, Sexual medicine, Internal medicine, Pharmacology & Pharmaceutical medicine
          Keywords: Rat growth hormone-releasing hormone, Pulsatile LH release, Secretin, Vasoactive intestinal peptide, VIP antagonist, [4Cl-<italic>D</italic>-Phe6, Leu17]VIP

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