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      Effect of [4CI- D-Phe 6, Leu 17]VIP on the Inhibition of Pulsatile LH Release by VIP and Related Peptides in the Ovariectomized Rat

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          Abstract

          Pulsatile LH secretion in the ovariectomized (OVX) rat is inhibited by intra-cerebroventricular (icv) infusion of vasoactive intestinal peptide (VIP). VIP, rat growth hormone-releasing hormone (rGRH) and secretin with and without an antagonist to VIP, [4Cl- D-Phe<sup>6</sup>, Leu<sup>17</sup>]VIP (VIPA), were infused icv into OVX rats. Both VIP and rGRH at an infusion rate of 3.5 nmol/h lowered mean LH concentrations and pulse frequency without affecting pulse amplitude, and these effects were blocked by concurrent infusion of VIPA (10.5 nmol/h). Secretin also inhibited pulsatile LH secretion, but was only fully effective at the higher infusion rate of 7 nmol/h. This effect of secretin was also blocked by concurrent infusion of 10.5 nmol/h of VIPA. These results suggest that all three of these peptide hormones inhibit pulsatile LH secretion by an interaction with VIP receptors.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1992
          1992
          07 April 2008
          : 56
          : 5
          : 646-652
          Affiliations
          Department of Physiology, University of Western Ontario, London, Ont., Canada
          Article
          126288 Neuroendocrinology 1992;56:646–652
          10.1159/000126288
          1488097
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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