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      Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator

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          Abstract

          <p class="first" id="P4">Hair loss, a common and distressing symptom, has been plaguing humans. Various pharmacological and nonpharmacological treatments have been widely studied to achieve the desired effect for hair regeneration. As a nonpharmacological physical approach, physiologically appropriate alternating electric field plays a key role in the field of regenerative tissue engineering. Here, a universal motion-activated and wearable electric stimulation device that can effectively promote hair regeneration <i>via</i> random body motions was designed. Significantly facilitated hair regeneration results were obtained from Sprague–Dawley rats and nude mice. Higher hair follicle density and longer hair shaft length were observed on Sprague–Dawley rats when the device was employed compared to conventional pharmacological treatments. The device can also improve the secretion of vascular endothelial growth factor and keratinocyte growth factor and thereby alleviate hair keratin disorder, increase the number of hair follicles, and promote hair regeneration on genetically defective nude mice. This work provides an effective hair regeneration strategy in the context of a nonpharmacological self-powered wearable electronic device. </p><p id="P5"> <div class="figure-container so-text-align-c"> <img alt="" class="figure" src="/document_file/06ffd404-a7ca-4156-82c3-2d470a50a86e/PubMedCentral/image/nihms-1051772-f0001.jpg"/> </div> </p>

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          Author and article information

          Journal
          ACS Nano
          ACS Nano
          American Chemical Society (ACS)
          1936-0851
          1936-086X
          September 10 2019
          September 10 2019
          Affiliations
          [1 ]Department of Materials Science and Engineering, University of Wisconsin—Madison, Madison, Wisconsin 53706, United States
          [2 ]State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P.R. China
          [3 ]Department of Radiology, University of Wisconsin—Madison, Madison, Wisconsin 53705, United States
          [4 ]Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Carson International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China
          Article
          10.1021/acsnano.9b03912
          6881522
          31503449
          3603bb42-6939-4994-a8f6-6bb0913b82ea
          © 2019
          History

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