8
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Inhibition of .ALPHA.-Glucosidase and .ALPHA.-Amylase by Flavonoids

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references10

          • Record: found
          • Abstract: not found
          • Article: not found

          α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 1. Survey of Natural Pigments with Potent Inhibitory Activity

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            α-Glucosidase Inhibitory Action of Natural Acylated Anthocyanins. 2. α-Glucosidase Inhibition by Isolated Acylated Anthocyanins

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action.

              In order to clarify the postprandial glucose suppression via alpha-glucosidase (AGH) inhibitory action by natural compounds, flavonoids were examined in this study. Among the flavonoids (luteolin, kaempferol, chrysin, and galangin), luteolin showed the potent maltase inhibitory activity with the IC50 of 2.3 mM, while less inhibitions were observed against sucrase. In addition, the effects of maltase inhibition by flavonoids were observed in the descending order of potency of luteolin > kaempferol > chrysin > galangin. Apparently, the AGH inhibition power greatly increased with the replacement of hydroxyl groups at 3' and 4'-position of the B-ring. However, the inhibitory power of luteolin was poorer than a therapeutic drug (acarbose: IC50; 430 nM). As a result of a single oral administration of maltose or sucrose (2 g/kg) in SD rats, no significant change in blood glucose level with the doses of 100 and 200 mg/kg of luteolin was observed. These findings strongly suggested that luteolin given at less than 200 mg/kg did not possess the ability to suppress the glucose production from carbohydrates through the inhibition of AGH action in the gut.
                Bookmark

                Author and article information

                Journal
                JNSVA5
                Journal of Nutritional Science and Vitaminology
                J Nutr Sci Vitaminol
                Center for Academic Publications Japan
                0301-4800
                1881-7742
                2006
                2006
                : 52
                : 2
                : 149-153
                Article
                10.3177/jnsv.52.149
                361d6efa-5fed-4ec7-a519-e78ae82b8783
                © 2006
                History

                Comments

                Comment on this article