Au@Ag nanoparticles decorated on cellulose paper could be worthful biomedical applications. Electrospinning technique is broadly employed for fabrication of nano and micro size fibers with a variety of biopolymers adding cellulose acetate nanofibers. Evolutions in cellulose research demonstrate that it is an anticipating material for the biomedical application. Nanofibers acquired by electrospinning technique were utilized in various biomedical applications. In this report, electrospinning of cellulose acetate, the solvent choice for cellulose acetate e-spun nanofabrication and decoration of AgNPs including shape and size for antimicrobial activity are argued.