The soluble guanylyl cyclase activator BAY 60-2770 inhibits murine allergic airways inflammation and human eosinophil chemotaxis.

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Abstract

Activators of soluble guanylyl cyclase (sGC) act preferentially in conditions of enzyme oxidation or haem group removal. This study was designed to investigate the effects of the sGC activator BAY 60-2770 in murine airways inflammation and human eosinophil chemotaxis.

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Journal ID (iso-abbrev): Pulm Pharmacol Ther

Title: Pulmonary pharmacology & therapeutics

Publisher: Elsevier BV

ISSN (Electronic): 1522-9629

ISSN (Print): 1094-5539

Publication date (Electronic): December 2016

Volume: 41

Affiliations

[1 ] Department of Pharmacology, Faculty of Medical Science, State University of Campinas (UNICAMP), Campinas, 13084-971, SP, Brazil.

[2 ] Department of Pharmacology, Faculty of Medical Science, State University of Campinas (UNICAMP), Campinas, 13084-971, SP, Brazil. Electronic address: antunes@fcm.unicamp.br.

Article

Publisher Item ID: S1094-5539(16)30145-6

DOI: 10.1016/j.pupt.2016.11.001

PubMed ID: 27816773

SO-VID: 3645809f-296b-415d-963c-ca3b01836309

History

Keywords: Inducible nitric oxide synthase,Th2 cytokines,Eotaxin,Cyclic GMP,Bone marrow

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Keywords: Inducible nitric oxide synthase, Th2 cytokines, Eotaxin, Cyclic GMP, Bone marrow

The soluble guanylyl cyclase activator BAY 60-2770 inhibits murine allergic airways inflammation and human eosinophil chemotaxis.

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