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      Comparison of in vitro effects of the pure antiandrogens OH-flutamide, casodex, and nilutamide on androgen-sensitive parameters

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      Urology

      Elsevier BV

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          Abstract

          A combination of flutamide (Eulexin) or nilutamide (Anandron) with a luteinizing hormone-releasing hormone (LHRH) agonist or orchiectomy is the only therapy demonstrated to prolong life in prostate cancer. Recently, the low 50-mg daily dose of Casodex, an analogue of the pure antiandrogen flutamide, was chosen for clinical studies on the basis that the compound was 5 to 10 times more potent than flutamide, as suggested by data obtained in the inappropriate intact rat model. The present study was designed to compare the in vitro antiandrogenic activity of OH-flutamide (OH-FLU), the active metabolite of flutamide, Casodex, and nilutamide.

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          Author and article information

          Journal
          Urology
          Urology
          Elsevier BV
          00904295
          April 1997
          April 1997
          : 49
          : 4
          : 580-589
          Article
          10.1016/S0090-4295(97)00029-0
          9111629
          © 1997

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