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      A clinicopathological study on the long-term efficacy of tonsillectomy in patients with IgA nephropathy.

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          Abstract

          Our study evaluated the clinical efficacy of tonsillectomy on the long-term renal survival in patients with primary IgA nephropathy (IgAN). Forty-six patients underwent tonsillectomy, and 74 patients did not. The mean of follow-up duration of all patients was 197.0+/-29.3 months (61-339 months). The baseline clinical and histological data at renal biopsy were not statistically different between the two groups with and without tonsillectomy. Five (10.9%) of the tonsillectomy group reached end stage renal failure (ESRF), whereas 19 (25.8%) of the non-tonsillectomy group did. The chi-square test between the two groups showed a significant difference (p <0.05). The renal survival of the tonsillectomy group was significantly higher than that of the non-tonsillectomy group by the Kaplan-Meier method with log-rank test (p <0.05). The Cox regression model also revealed that tonsillectomy had a significant favorable impact on the renal survival in long-term follow-up duration (p <0.05). Although our study was done by retrospective analyses, all the results proved that tonsillectomy had significant favorable effects on the long-term renal survival in patients with IgAN.

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          Author and article information

          Journal
          Acta Otolaryngol Suppl
          Acta oto-laryngologica. Supplementum
          0365-5237
          0365-5237
          Dec 2004
          : 555
          Affiliations
          [1 ] Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. snishi@med.niigata-u.ac.jp
          Article
          15768798

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