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      Essential brain structural alterations in major depressive disorder: A voxel-wise meta-analysis on first episode, medication-naive patients.

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          Abstract

          Because brain morphological abnormalities in major depressive disorder (MDD) may be modulated by medication and episodes, previous meta-analyses of voxel-based morphometry (VBM) studies therefore have been biased for including medicated patients or medication-free patients who had ever received drugs, as well as patients with different episodes. We sought to identify the essential morphological features without the interference of medication and episodes in MDD.

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          Author and article information

          Journal
          J Affect Disord
          Journal of affective disorders
          Elsevier BV
          1573-2517
          0165-0327
          Jul 15 2016
          : 199
          Affiliations
          [1 ] Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR China.
          [2 ] Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, PR China.
          [3 ] Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR China; Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, PR China. Electronic address: zhiyunjia@hotmail.com.
          [4 ] Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR China; Department of Psychology, School of Public Administration, Sichuan University, Chengdu, PR China. Electronic address: qiyonggong@hmrrc.org.cn.
          Article
          S0165-0327(16)30107-0
          10.1016/j.jad.2016.04.001
          27100056

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