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      Regulatory T cells and immune tolerance.

      1 , , ,

      Cell

      Elsevier BV

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          Abstract

          Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          May 30 2008
          : 133
          : 5
          Affiliations
          [1 ] Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. shimon@frontier.kyoto-u.ac.jp
          Article
          S0092-8674(08)00624-7
          10.1016/j.cell.2008.05.009
          18510923

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