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      Respiratory Muscle Weakness in Uremic Patients under Continuous Ambulatory Peritoneal Dialysis

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          Abstract

          The increasingly frequent use of continuous ambulatory peritoneal dialysis (CAPD) as substitutive therapy in terminal renal failure has induced the investigation of the advantages and disadvantages of this therapeutic modality. The effects of CAPD on pulmonary function are one of the aspects currently under study. Based on previous data suggesting the existence of extrapulmonary ventilatory restriction in uremic patients under CAPD, we have studied in these patients the respiratory muscle function as expressed in the maximal inspiratory pressure (MIP) and assessed the impact of the infusion of 2 liters of dialysis fluid into the peritoneal cavity on both MIP and the pulmonary volumes. Uremic patients evidenced significantly lower MIP values as compared with healthy controls. The filling of the peritoneal cavity induced, both in the supine and in the sitting position, a restrictive effect and an increase in the inspiratory capacity. We conclude that uremic patients under CAPD evidence a respiratory muscle dysfunction of as yet unclear cause. Our findings further suggest that the infusion of 2 liters of dialysis fluid into the peritoneal cavity induces not only a restrictive effect, but also an increase in the strength of the respiratory muscles, the latter effect being probably due to increased diaphragmatic contractility.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          03 December 2008
          : 36
          : 4
          : 219-223
          Affiliations
          aNephrology Service, Ciudad Sanitaria LA PAZ, Medical School of the Universidad Autónoma de Madrid, and bPneumology Service, Hospital Victoria Eugenia, Madrid, Spain
          Article
          183157 Nephron 1984;36:219–223
          10.1159/000183157
          6709114
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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