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      Effects of a Selective Thromboxane A 2 Synthetase Inhibitor on Immune Complex Glomerulonephritis

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          It has been reported that agents which block the prostaglandin system inhibit the development of glomerulonephritis. However, the mechanisms of these effects are not clear. We studied the effect of a selective thromboxane A<sub>2</sub> (TXA<sub>2</sub>) synthetase inhibitor, 1-benzylimidazole (BIm), on the immune complex glomerulonephritis produced by bovine serum albumin (BSA) in New Zealand white rabbits. As the BSA nephritis developed, there was no change of creatinine (Cr), serum urea nitrogen (SUN), or creatinine clearance (Ccr), but urinary protein excretion increased almost 3-fold. Coagulation and fibrinolytic studies suggested a hypercoagulable state and increased fibrinolytic activity. Platelet aggregation showed the reduction of maximum aggregation induced by ADP and collagen. Histological examination by light microscopy, immunofiuorescence, and electron microscopy revealed glomerular polymorphonuclear leukocyte (PMN) infiltration, mononuclear cell (MON) proliferation, and fibrin deposition. In 70% of the rabbits, IgG and C3 deposits were seen by immunofluorescene mainly in mesangial areas. The administration of BIm to BSA nephritis had no effects on Cr, SUN or Ccr, but it significantly lessened the proteinuria. The study of coagulation and fibrinolytic activity suggested a less hypercoagulable state, and more efficient fibrinolysis occurred than in the group without BIm. BIm tended to normalize platelet aggregation. It also lessened the histological PMN infiltration (p < 0.05), MON proliferation (p < 0.01), and fibrin deposition (p < 0.05). These data suggest that TxA<sub>2</sub> may play an important pathogenetic role in the development and progression of glomerulonephritis.

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          Author and article information

          S. Karger AG
          03 December 2008
          : 36
          : 1
          : 38-45
          aDepartment of Internal Medicine, Tokyo Medical and Dental University, Tokyo; bDepartment of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan
          183113 Nephron 1984;36:38–45
          © 1984 S. Karger AG, Basel

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          Pages: 8
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