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Abstract
Cirrhosis is defined as the histological development of regenerative nodules surrounded
by fibrous bands in response to chronic liver injury, which leads to portal hypertension
and end-stage liver disease. Recent advances in the understanding of the natural history
and pathophysiology of cirrhosis, and in treatment of its complications, have resulted
in improved management, quality of life, and life expectancy of patients. Liver transplantation
remains the only curative option for a selected group of patients, but pharmacological
treatments that can halt progression to decompensated cirrhosis or even reverse cirrhosis
are currently being developed. This Seminar focuses on the diagnosis, complications,
and management of cirrhosis, and new clinical and scientific developments.