The study examined important diverse sociodemographic, medical and psychological variables as potential predictors of sexual activity frequency/satisfaction in male patients following a first acute myocardial infarction (AMI). The sample comprised 276 Israeli male patients, age range 30–65 years, with a documented first AMI who were admitted to any of eight medical centers in Israel. All patients were sexually active prior to AMI. Data were elicited from interviews and medical charts on two occasions: before discharge and 3–6 months after AMI. The research variables explained a greater extent of the variance in sexual activity frequency than in satisfaction 3–6 months after AMI (32 and 23%, respectively). Sexual activity frequency/satisfaction prior to AMI were the major contributors to frequency/satisfaction after AMI. Of the other variables, age and education were the major contributors to sexual activity frequency; of these two variables, age was the sole contributor to sexual satisfaction. Medical and psychological variables (diabetes and depression) were minor contributors.