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      The angiotensin–converting enzyme gene family: genomics and pharmacology

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      Trends in Pharmacological Sciences
      Elsevier BV

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          Abstract

          Modulation of the renin-angiotensin system (RAS), and particularly inhibition of angiotensin-converting enzyme (ACE), a zinc metallopeptidase, has long been a prime strategy in the treatment of hypertension. However, other angiotensin metabolites are gaining in importance as our understanding of the RAS increases. Recently, genomic approaches have identified the first human homologue of ACE, termed ACEH (or ACE2). ACEH differs in specificity and physiological roles from ACE, which opens a potential new area for discovery biology. The gene that encodes collectrin, a homologue of ACEH, is upregulated in response to renal injury. Collectrin lacks a catalytic domain, which indicates that there is more to ACE-like function than simple peptide hydrolysis.

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          Author and article information

          Journal
          Trends in Pharmacological Sciences
          Trends in Pharmacological Sciences
          Elsevier BV
          01656147
          April 2002
          April 2002
          : 23
          : 4
          : 177-183
          Article
          10.1016/S0165-6147(00)01994-5
          11931993
          371f00f5-3b3d-40d4-a389-baf049d61b9a
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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