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      Anti-allergic and anti-inflammatory activity of Phellinus linteus grown on Panax ginseng

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          Abstract

          Panax ginseng (PG) or Phellinus linteus (PL) have been widely used as traditional medicine owing to their many biological activities, including anti-inflammatory and anti-allergic activities. Previously, our group produced PL that was grown on PG media (PGP) to enhance anti-cancer activities of PGP. Here we studied the anti-allergic activity of PGP and its mechanism of action. The ethyl acetate fraction of PGP exhibited the anti-allergic activity by suppressing β-hexosaminidase release, a marker of degranulation, from antigen/immunoglobulin E (IgE)-stimulated RBL-2H3 cells. Exposure to PGP inhibited the level of antigen/IgE-induced TNF-alpha in RBL-2H3 cells. It markedly suppressed the phosphorylation of spleen associated tyrosine kinase, GRB2-associated-binding protein 2 (Gab2) and extracellular signal-regulated kinases proteins, which are required for the degranulation and production of pro-inflammatory cytokines. Its anti-inflammatory activity was observed in lipopolysaccharide-stimulated RAW 264.7 cells. In addition, PGP contained higher contents of Rg1 than PG. Our findings suggest that PGP might be developed as a therapeutic agent for IgE-mediated allergic diseases.

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          Author and article information

          Contributors
          +82-31-750-5382 , +82-2-455-5517 , nimpi79@hanmail.net
          Journal
          Food Sci Biotechnol
          Food Sci. Biotechnol
          Food Science and Biotechnology
          The Korean Society of Food Science and Technology (Seoul )
          1226-7708
          2092-6456
          30 April 2017
          2017
          : 26
          : 2
          : 467-472
          Affiliations
          ISNI 0000 0004 0647 2973, GRID grid.256155.0, Department of Food Science and Biotechnology, College of BioNano Technology, , Gachon University, ; Seongnam, Gyeonggi, 13120 Korea
          Article
          PMC6049448 PMC6049448 6049448 64
          10.1007/s10068-017-0064-8
          6049448
          30263566
          37215733-ad25-468a-9632-98987e41d7d1
          © The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht 2017
          History
          : 14 July 2016
          : 21 December 2016
          : 6 January 2017
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          Article
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          © The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht 2017

          anti-inflammatory activity,anti-allergic activity,PGP

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