14
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Nanomaterial Applications in Photothermal Therapy for Cancer

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          As a result of their unique compositions and properties, nanomaterials have recently seen a tremendous increase in use for novel cancer therapies. By taking advantage of the optical absorption of near-infrared light, researchers have utilized nanostructures such as carbon nanotubes, gold nanorods, and graphene oxide sheets to enhance photothermal therapies and target the effect on the tumor tissue. However, new uses for nanomaterials in targeted cancer therapy are coming to light, and the efficacy of photothermal therapy has increased dramatically. In this work, we review some of the current applications of nanomaterials to enhance photothermal therapy, specifically as photothermal absorbers, drug delivery vehicles, photoimmunological agents, and theranostic tools.

          Related collections

          Most cited references51

          • Record: found
          • Abstract: found
          • Article: not found

          In vitro toxicity evaluation of graphene oxide on A549 cells.

          Graphene and its derivatives have attracted great research interest for their potential applications in electronics, energy, materials and biomedical areas. However, little information of their toxicity and biocompatibility is available. Herein, we performed a comprehensive study on the toxicity of graphene oxide (GO) by examining the influences of GO on the morphology, viability, mortality and membrane integrity of A549 cells. The results suggest that GO does not enter A549 cell and has no obvious cytotoxicity. But GO can cause a dose-dependent oxidative stress in cell and induce a slight loss of cell viability at high concentration. These effects are dose and size related, and should be considered in the development of bio-applications of GO. Overall, GO is a pretty safe material at cellular level, which is confirmed by the favorable cell growth on GO film. © 2010 Elsevier Ireland Ltd. All rights reserved.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Gold nanorods: Synthesis, characterization and applications

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              PEG-modified gold nanorods with a stealth character for in vivo applications.

              Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.
                Bookmark

                Author and article information

                Journal
                Materials (Basel)
                Materials (Basel)
                materials
                Materials
                MDPI
                1996-1944
                07 March 2019
                March 2019
                : 12
                : 5
                : 779
                Affiliations
                [1 ]Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, College of Mathematics and Science, University of Central Oklahoma, Edmond, OH 73034, USA; adoughty1@ 123456uco.edu (A.C.V.D.); ahoover7@ 123456uco.edu (A.R.H.); elayton3@ 123456uco.edu (E.L.)
                [2 ]Department of Mathematics and Statistics, College of Mathematics and Science, University of Central Oklahoma, Edmond, OH 73034, USA; cmurray@ 123456uco.edu
                [3 ]Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OH 73104, USA; Eric-Howard@ 123456ouhsc.edu
                Author notes
                [* ]Correspondence: wchen@ 123456uco.edu ; Tel.: +1-(405)-974-5147
                Article
                materials-12-00779
                10.3390/ma12050779
                6427777
                30866416
                3727d133-172c-4f33-a419-d2666626da48
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 21 December 2018
                : 27 February 2019
                Categories
                Review

                cancer,metastatic,photothermal therapy,ablation,nanomaterials,combination therapy

                Comments

                Comment on this article