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MicroRNAs in cancer: biomarkers, functions and therapy
Author(s):
Josie Hayes
,
Pier Paolo Peruzzi
,
Sean Lawler
Publication date
Created:
August 2014
Publication date
(Print):
August 2014
Journal:
Trends in Molecular Medicine
Publisher:
Elsevier BV
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PubMed
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The importance of microRNAs in cancer has been underlined by the identification of alterations in microRNA target binding sites and the microRNA processing machinery in tumor cells. Clinical trials utilizing microRNA profiling for patient prognosis and clinical response are now underway, and the first microRNA mimic entered the clinic for cancer therapy in 2013. In this article we review the potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy. Copyright © 2014 Elsevier Ltd. All rights reserved.
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Journal of Circulating Biomarkers
Author and article information
Journal
Title:
Trends in Molecular Medicine
Abbreviated Title:
Trends in Molecular Medicine
Publisher:
Elsevier BV
ISSN (Print):
14714914
Publication date Created:
August 2014
Publication date (Print):
August 2014
Volume
: 20
Issue
: 8
Pages
: 460-469
Article
DOI:
10.1016/j.molmed.2014.06.005
PubMed ID:
25027972
SO-VID:
37375e01-c4b0-4058-9d86-b154b6268b06
Copyright ©
© 2014
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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