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      The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder.

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          Abstract

          A key tenet of bone tissue engineering is the development of scaffold materials that can stimulate stem cell differentiation in the absence of chemical treatment to become osteoblasts without compromising material properties. At present, conventional implant materials fail owing to encapsulation by soft tissue, rather than direct bone bonding. Here, we demonstrate the use of nanoscale disorder to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements. This approach has similar efficiency to that of cells cultured with osteogenic media. In addition, the current studies show that topographically treated MSCs have a distinct differentiation profile compared with those treated with osteogenic media, which has implications for cell therapies.

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          Author and article information

          Journal
          Nat Mater
          Nature materials
          Springer Science and Business Media LLC
          1476-1122
          1476-1122
          Dec 2007
          : 6
          : 12
          Affiliations
          [1 ] Centre for Cell Engineering, Joseph Black Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK. m.dalby@bio.gla.ac.uk
          Article
          nmat2013
          10.1038/nmat2013
          17891143
          3739b311-8d1d-4dd8-8666-2ce7dab7da12
          History

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