Blog
About

  • Record: found
  • Abstract: not found
  • Article: not found

Electrochemical impedance spectroscopy: an overview of bioanalytical applications

,

Analytical Methods

Royal Society of Chemistry (RSC)

Read this article at

ScienceOpenPublisher
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Related collections

      Most cited references 128

      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Two Dimensional Atomic Crystals

      We report free-standing atomic crystals that are strictly 2D and can be viewed as individual atomic planes pulled out of bulk crystals or as unrolled single-wall nanotubes. By using micromechanical cleavage, we have prepared and studied a variety of 2D crystals, including single layers of boron nitride, graphite, several dichalcogenides and complex oxides. These atomically-thin sheets (essentially gigantic 2D molecules unprotected from the immediate environment) are stable under ambient conditions, exhibit high crystal quality and are continuous on a macroscopic scale.
        Bookmark
        • Record: found
        • Abstract: found
        • Article: not found

        Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species.

         Y Cui,  Qi Wei,  Ming Q. Wei (2001)
        Boron-doped silicon nanowires (SiNWs) were used to create highly sensitive, real-time electrically based sensors for biological and chemical species. Amine- and oxide-functionalized SiNWs exhibit pH-dependent conductance that was linear over a large dynamic range and could be understood in terms of the change in surface charge during protonation and deprotonation. Biotin-modified SiNWs were used to detect streptavidin down to at least a picomolar concentration range. In addition, antigen-functionalized SiNWs show reversible antibody binding and concentration-dependent detection in real time. Lastly, detection of the reversible binding of the metabolic indicator Ca2+ was demonstrated. The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics.
          Bookmark
          • Record: found
          • Abstract: found
          • Article: not found

          Multiplexed electrical detection of cancer markers with nanowire sensor arrays.

          We describe highly sensitive, label-free, multiplexed electrical detection of cancer markers using silicon-nanowire field-effect devices in which distinct nanowires and surface receptors are incorporated into arrays. Protein markers were routinely detected at femtomolar concentrations with high selectivity, and simultaneous incorporation of control nanowires enabled discrimination against false positives. Nanowire arrays allowed highly selective and sensitive multiplexed detection of prostate specific antigen (PSA), PSA-alpha1-antichymotrypsin, carcinoembryonic antigen and mucin-1, including detection to at least 0.9 pg/ml in undiluted serum samples. In addition, nucleic acid receptors enabled real-time assays of the binding, activity and small-molecule inhibition of telomerase using unamplified extracts from as few as ten tumor cells. The capability for multiplexed real-time monitoring of protein markers and telomerase activity with high sensitivity and selectivity in clinically relevant samples opens up substantial possibilities for diagnosis and treatment of cancer and other complex diseases.
            Bookmark

            Author and article information

            Journal
            AMNECT
            Analytical Methods
            Anal. Methods
            Royal Society of Chemistry (RSC)
            1759-9660
            1759-9679
            2013
            2013
            : 5
            : 5
            : 1098
            10.1039/c3ay26476a
            © 2013
            Product
            Self URI (article page): http://xlink.rsc.org/?DOI=c3ay26476a

            Comments

            Comment on this article