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      Intracellular pH and Electrolyte Content of Skeletal Muscle in Patients with Chronic Renal Acidosis

      , , , , , ,

      Nephron

      S. Karger AG

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          Abstract

          The intracellular pH (pHi) of skeletal muscle, obtained by needle biopsy, was determined in 14 patients with chronic non-terminal renal acidosis and 6 normal subjects. Furthermore, the muscle composition in electrolytes and alkali-soluble protein nitrogen was analyzed. In patients with chronic renal acidosis the mean pHi value (6.88 ± 0.12) was not significantly different from that of the controls (6.92 ± 0.11). No correlation between intra- and extracellular pH values nor between pHi and plasma creatinine or cell sodium ion concentration was found. A significant direct linear relationship between pHi and potassium content in skeletal muscle was observed. These results suggest that potassium depletion is partly related to the increase in intracellular hydrogen ion concentration.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1970
          1970
          26 November 2008
          : 7
          : 5
          : 481-487
          Affiliations
          Istituto di Patologia Medica dell’Università di Padova, Padova
          Article
          179849 Nephron 1970;7:481–487
          10.1159/000179849
          5501301
          © 1970 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Short Paper

          Cardiovascular Medicine, Nephrology

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