15
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Inflammatory processes in renal fibrosis.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Many types of kidney injury induce inflammation as a protective response. However, unresolved inflammation promotes progressive renal fibrosis, which can culminate in end-stage renal disease. Kidney inflammation involves cells of the immune system as well as activation of intrinsic renal cells, with the consequent production and release of profibrotic cytokines and growth factors that drive the fibrotic process. In glomerular diseases, the development of glomerular inflammation precedes interstitial fibrosis; although the mechanisms linking these events are poorly understood, an important role for tubular epithelial cells in mediating this link is gaining support. Data have implicated macrophages in promoting both glomerular and interstitial fibrosis, whereas limited evidence suggests that CD4(+) T cells and mast cells are involved in interstitial fibrosis. However, macrophages can also promote renal repair when the cause of renal injury can be resolved, highlighting their plasticity. Understanding the mechanisms by which inflammation drives renal fibrosis is necessary to facilitate the development of therapeutics to halt the progression of chronic kidney disease.

          Related collections

          Author and article information

          Journal
          Nat Rev Nephrol
          Nature reviews. Nephrology
          Springer Science and Business Media LLC
          1759-507X
          1759-5061
          Sep 2014
          : 10
          : 9
          Affiliations
          [1 ] School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
          [2 ] Monash University Department of Medicine, 246 Clayton Road, Clayton, Melbourne, Vic 3168, Australia.
          [3 ] Li Ka Shing Institute of Health Sciences and Department of Medicine &Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
          Article
          nrneph.2014.114
          10.1038/nrneph.2014.114
          24981817
          376f0418-f2e9-4ef0-aef8-f81b33e84148
          History

          Comments

          Comment on this article