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      Left ventricular noncompaction: a new form of heart failure.

      Heart failure clinics

      therapy, diagnosis, complications, Ventricular Dysfunction, Left, genetics, TOR Serine-Threonine Kinases, NFATC Transcription Factors, cytology, Myocardium, Mutation, Muscular Diseases, Mitochondrial Myopathies, Magnetic Resonance Imaging, Cine, MERRF Syndrome, LIM Domain Proteins, Kearns-Sayre Syndrome, Incidence, Humans, Homeodomain Proteins, pathology, Heart Ventricles, Heart Defects, Congenital, Electrocardiography, Echocardiography, Disease Models, Animal, DNA, Mitochondrial, Carrier Proteins, Cardiomyopathies, Barth Syndrome, Arrhythmias, Cardiac, Animals, Adaptor Proteins, Signal Transducing

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          Abstract

          In this article the newly classified cardiomyopathy known as left ventricular noncompaction is discussed. This genetic inherited form of heart disease has substantial risk of heart failure, stroke, metabolic derangement, arrhythmias, and sudden cardiac death. The disorder seems to occur because of an arrest of the normal process of development, and the genes identified to date seem to encode for cytoskeletal or sarcomeric proteins. These features are outlined. Copyright © 2010. Published by Elsevier Inc.

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          Journal
          10.1016/j.hfc.2010.06.005
          20869646

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