Efficacy of transcutaneous electrical acupoint stimulation combined with diazepam for acute alcohol withdrawal syndrome: A double-blind randomized sham-controlled trial

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Objective

To compare the efficacy of transcutaneous electrical acupoint stimulation (TEAS) combined with diazepam against diazepam alone for treatment of acute alcohol withdrawal syndrome (AWS).

Methods

In this double-blind randomized sham-controlled trial, men with acute AWS were randomly allocated to either a group treated with TEAS combined with diazepam (n = 57) or a control group treated with sham TEAS combined with diazepam (n = 60). Treatment was performed at four acupoints twice a day for 14 days. The Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar), visual analogue scale (VAS), Pittsburgh Sleep Quality Index (PSQI) and modified Epworth Sleepiness Scale (mESS) were used to evaluate treatment efficacy.

Results

All scores improved significantly in both groups during the trial. CIWA-Ar scores were lower in the TEAS group than in the control group from day 3 until the end of observation. VAS and mESS scores were also lower in the TEAS group than in the control group on day 7. VAS and PSQI scores were lower in the TEAS group on day 14.

Conclusion

Combining diazepam with TEAS may result in milder AWS symptoms than diazepam alone, improve sleep quality and reduce sleepiness.

Related collections

Most cited references 28

Record: found
Abstract: found
Article: not found

Safety of acupuncture: results of a prospective observational study with 229,230 patients and introduction of a medical information and consent form.

Claudia Witt, Daniel Pach, Benno Brinkhaus … (2009)

To evaluate the safety of acupuncture in a large number of patients receiving conventional health care and, based on these results, to develop a new medical consent form for acupuncture. The prospective observational study included patients who received acupuncture treatment for chronic osteoarthritis pain of the knee or hip, low back pain, neck pain or headache, allergic rhinitis, asthma, or dysmenorrhoea. After treatment, all patients documented adverse events associated with acupuncture (defined as adverse effects). Patients who reported a need for treatment due to an adverse effect completed an additional standardised questionnaire on the most important adverse effect. Based on this data and considering ethical and legal aspects a new consent form was developed. A total of 229,230 patients received on average 10.2 +/- 3.0 acupuncture treatments. Altogether, 19,726 patients (8.6%) reported experiencing at least one adverse effect and 4,963 (2.2%) reported one which required treatment. Common adverse effects were bleedings or haematoma (6.1% of patients, 58% of all adverse effects), pain (1.7%) and vegetative symptoms (0.7%). Two patients experienced a pneumothorax (one needed hospital treatment, the other observation only). The longest duration of a side effect was 180 days (nerve lesion of the lower limb). The resulting medical consent form consists of five modules: Introduction to acupuncture and moxibustion, Risks of acupuncture treatment, Conditions which can increase the risk, Doctor's statement, and Consent. Acupuncture provided by physicians is a relatively safe treatment and the proposed consent form could support both patients and professionals in the process of obtaining informed consent. Copyright (c) 2009 S. Karger AG, Basel.

0 comments Cited 149 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Electroacupuncture: mechanisms and clinical application.

George A. Ulett, Songping Han, Ji-sheng Han (1998)

Acupuncture is an ancient Chinese method to treat diseases and relieve pain. We have conducted a series of studies to examine the mechanisms of this ancient method for pain relief. This article reviews some of our major findings. Our studies showed that acupuncture produces analgesic effect and that electroacupuncture (EA) is more effective than manual acupuncture. Furthermore, electrical stimulation via skin patch electrodes is as effective as EA. The induction and recovering profiles of acupuncture analgesia suggest the involvement of humoral factors. This notion was supported by cross-perfusion experiments in which acupuncture-induced analgesic effect was transferred from the donor rabbit to the recipient rabbit when the cerebrospinal fluid (CSF) was transferred. The prevention of EA-induced analgesia by naloxone and by antiserum against endorphins suggests that endorphins are involved. More recent work demonstrated the release of endorphins into CSF following EA. In addition, low frequency (2 Hz) and high frequency (100 Hz) of EA selectively induces the release of enkephalins and dynorphins in both experimental animals and humans. Clinical studies suggesting its effectiveness for the treatment of various types of pain, depression, anxiety, spinally induced muscle spasm, stroke, gastrointestinal disorders, and drug addiction were also discussed.

0 comments Cited 149 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.

Umesh Jain, Boris Perelman, Miriam A Shelef … (2003)

The response to acupuncture of 18 anxious adult subjects who complained of insomnia was assessed in an open prepost clinical trial study. Five weeks of acupuncture treatment was associated with a significant (p = 0.002) nocturnal increase in endogenous melatonin secretion (as measured in urine) and significant improvements in polysomnographic measures of sleep onset latency (p = 0.003), arousal index (p = 0.001), total sleep time (p = 0.001), and sleep efficiency (p = 0.002). Significant reductions in state (p = 0.049) and trait (p = 0.004) anxiety scores were also found. These objective findings are consistent with clinical reports of acupuncture's relaxant effects. Acupuncture treatment may be of value for some categories of anxious patients with insomnia.

0 comments Cited 30 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): J Int Med Res

Journal ID (iso-abbrev): J. Int. Med. Res

Journal ID (publisher-id): IMR

Journal ID (hwp): spimr

Title: The Journal of International Medical Research

Publisher: SAGE Publications (Sage UK: London, England )

ISSN (Print): 0300-0605

ISSN (Electronic): 1473-2300

Publication date (Electronic): 28 April 2020

Publication date Collection: April 2020

Volume: 48

Issue: 4

Electronic Location Identifier: 0300060520910052

Affiliations

[1 ]Department of Neurology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, China

[2 ]Department of Substance Abuse, Qingdao Mental Health Center, Qingdao, China

[3 ]Department of Substance Abuse, Shandong Mental Health Center Affiliated to Jining Medical University, Jinan, China

Author notes

[*]

These authors contributed equally to this work.

[*]Xu Chen, Department of Substance Abuse, Shandong Mental Health Center Affiliated to Jining Medical University, 49 Wenhua East Road, Jinan 250014, China. Email: chenxu99jn@ 123456hotmail.com

Author information

Xu Chen https://orcid.org/0000-0003-1401-1571

Article

Publisher ID: 10.1177_0300060520910052

DOI: 10.1177/0300060520910052

PMC ID: 7218471

PubMed ID: 32340502

SO-VID: 37907b66-210c-4bc6-8b31-88d091e76636

License:

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

History

Date received : 4 June 2019

Date accepted : 23 January 2020

Funding

Funded by: Jining Medical University Teachers Scientific Research Supportive Fund;

Award ID: JY2017JS001

Funded by: Shandong Medical and Health Science & Technology Development Plan Project;

Award ID: 2016ws0398

Custom metadata

edited-state corrected-proof

typesetter ts2

Keywords: transcutaneous electrical acupoint stimulation,diazepam,alcohol withdrawal syndrome,randomized controlled trial,sleep quality,daytime sleepiness

Data availability:

Keywords: transcutaneous electrical acupoint stimulation, diazepam, alcohol withdrawal syndrome, randomized controlled trial, sleep quality, daytime sleepiness

Efficacy of transcutaneous electrical acupoint stimulation combined with diazepam for acute alcohol withdrawal syndrome: A double-blind randomized sham-controlled trial

Read this article at

Abstract

Objective

Methods

Results

Conclusion

Related collections

International Journal of Medicine and Medical Research

Most cited references 28

Safety of acupuncture: results of a prospective observational study with 229,230 patients and introduction of a medical information and consent form.

Electroacupuncture: mechanisms and clinical application.

Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report.

Author and article information

Journal

Affiliations

Author notes

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 122

Cited by 2

Most referenced authors 428