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      Membrane tension and membrane fusion.

      1 , 2
      Current opinion in structural biology
      Elsevier BV

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          Abstract

          Diverse cell biological processes that involve shaping and remodeling of cell membranes are regulated by membrane lateral tension. Here we focus on the role of tension in driving membrane fusion. We discuss the physics of membrane tension, forces that can generate the tension in plasma membrane of a cell, and the hypothesis that tension powers expansion of membrane fusion pores in late stages of cell-to-cell and exocytotic fusion. We propose that fusion pore expansion can require unusually large membrane tensions or, alternatively, low line tensions of the pore resulting from accumulation in the pore rim of membrane-bending proteins. Increase of the inter-membrane distance facilitates the reaction.

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          Author and article information

          Journal
          Curr. Opin. Struct. Biol.
          Current opinion in structural biology
          Elsevier BV
          1879-033X
          0959-440X
          Aug 2015
          : 33
          Affiliations
          [1 ] Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel. Electronic address: michk@post.tau.ac.il.
          [2 ] Section on Membrane Biology, Program of Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: chernoml@mail.nih.gov.
          Article
          S0959-440X(15)00108-6 NIHMS713248
          10.1016/j.sbi.2015.07.010
          4641764
          26282924
          37a20173-70e5-4376-b525-ac92c038f93b
          History

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