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      Dynamics and Regulation of TSH Secretion by Superfused Anterior Pituitary Cells

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          Abstract

          Superfused dispersed cells respond rapidly to 2- to 10-min pulses of TRH (10-10 to 10<sup>-7</sup> M) in a dose-dependent manner. The effects of decreasing the stimulus duration can be overcome by a proportional increase in concentration of TRH. A TRH stimulus of 10 min or greater duration results in a sharp peak in TSH secretion followed by a lower plateau. Somatostatin (10<sup>-8</sup> M) inhibits the response to TRH (5 X 10<sup>-9</sup> M). T<sub>3</sub> (2.0 µg/dl) inhibits TRH-induced TSH secretion by superfused pituitary fragments, but not by dispersed cells. Corticosterone (50 µg/dl), however, inhibits crude CRF-induced ACTH secretion by such cells.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1981
          1981
          25 November 2008
          : 14
          : 1
          : 1-17
          Affiliations
          Department of Physiology, School of Medicine, West Virginia University, Morgantown, W. Va., USA
          Article
          179352 Horm Res 1981;14:1–17
          10.1159/000179352
          6114918
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 17
          Categories
          Original Paper

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