Dynamics and Regulation of TSH Secretion by Superfused Anterior Pituitary Cells

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Abstract

Superfused dispersed cells respond rapidly to 2- to 10-min pulses of TRH (10-10 to 10-7 M) in a dose-dependent manner. The effects of decreasing the stimulus duration can be overcome by a proportional increase in concentration of TRH. A TRH stimulus of 10 min or greater duration results in a sharp peak in TSH secretion followed by a lower plateau. Somatostatin (10-8 M) inhibits the response to TRH (5 X 10-9 M). T3 (2.0 µg/dl) inhibits TRH-induced TSH secretion by superfused pituitary fragments, but not by dispersed cells. Corticosterone (50 µg/dl), however, inhibits crude CRF-induced ACTH secretion by such cells.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1981

Publication date (Print): 1981

Publication date (Electronic): 25 November 2008

Volume: 14

Issue: 1

Pages: 1-17

Affiliations

Department of Physiology, School of Medicine, West Virginia University, Morgantown, W. Va., USA

Article

Publisher ID: 179352 Other ID: Horm Res 1981;14:1–17

DOI: 10.1159/000179352

PubMed ID: 6114918

SO-VID: 37e052d1-0b7c-410a-872d-acd073aa8ff3

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 11 August 1980

Date accepted : 09 January 1981

Page count

Pages: 17

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