8
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Graves' disease during immune reconstitution after highly active antiretroviral therapy for HIV infection: evidence of thymic dysfunction.

      AIDS Research and Human Retroviruses
      Adult, Antigens, CD30, blood, Antiretroviral Therapy, Highly Active, adverse effects, Autoantibodies, Autoimmunity, CD4-Positive T-Lymphocytes, immunology, CD8-Positive T-Lymphocytes, Case-Control Studies, Graves Disease, etiology, HIV Infections, complications, drug therapy, Humans, Lymphocyte Count, Male, Receptors, Thyrotropin, Regeneration, Thymus Gland, physiopathology, radiography

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A patient with HIV infection who experienced immune reconstitution after highly active antiretroviral therapy (HAART) [increase in CD4 T cell count from <1/microl to >600/microl] presented with severe Graves' disease 32 months after commencing HAART. A comprehensive clinical and laboratory study demonstrated pronounced regional lymphadenopathy and thymic enlargement at presentation, and that the onset of thyrotropin receptor antibody production was associated with increased production of soluble CD30 (a marker of type 2 immune responses). Blood naive CD8 T cell counts and TREC levels in both CD4 and CD8 T cells were increased at multiple time points compared with carefully selected controls. We conclude that the Graves' disease in this patient was associated with abnormally high blood counts of thymus-derived T cells, and propose that Graves' disease after HAART in this and other HIV patients may result from failure to delete autoreactive T cell clones in the regenerating thymus.

          Related collections

          Author and article information

          Comments

          Comment on this article