Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo.

Gilchrist, Mark; Winyard, Paul G.; Fulford, Jon; Anning, Christine; Shore, Angela C.; Benjamin, Nigel

doi:10.1016/j.niox.2014.05.003

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Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo.

Author(s): Mark Gilchrist ¹ , Paul G Winyard ² , Jon Fulford ² , Christine Anning ² , Angela C Shore ² , Nigel Benjamin ²

Publication date (Electronic): Aug 31 2014

Journal: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society

Keywords: Beetroot juice, Beetroot placebo, Cognitive function, Dietary nitrate, Nitrate depleted placebo, Nitrite, Reaction time, Type 2 diabetes

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Abstract

In this substudy of the effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes, we report the development of a novel nitrate depleted beetroot juice for use clinical trials and determine if dietary nitrate supplementation improved cognitive function in patients with type 2 diabetes mellitus.

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Journal ID (iso-abbrev): Nitric Oxide

Title: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society

ISSN (Electronic): 1089-8611

ISSN (Print): 1089-8603

Publication date (Electronic): Aug 31 2014

Volume: 40

Affiliations

[1 ] NIHR Exeter Clinical Research Facility and Institute of Biomedical and Clinical Science, University of Exeter Medical School (Previously Peninsula College of Medicine and Dentistry), University of Exeter, Exeter EX2 5AX, UK. Electronic address: m.gilchrist@exeter.ac.uk.

[2 ] NIHR Exeter Clinical Research Facility and Institute of Biomedical and Clinical Science, University of Exeter Medical School (Previously Peninsula College of Medicine and Dentistry), University of Exeter, Exeter EX2 5AX, UK.

Article

Publisher Item ID: S1089-8603(14)00228-6

DOI: 10.1016/j.niox.2014.05.003

PubMed ID: 24858657

SO-VID: 380427e6-f192-4ceb-b96b-c18408234b99

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Keywords: Beetroot juice,Beetroot placebo,Cognitive function,Dietary nitrate,Nitrate depleted placebo,Nitrite,Reaction time,Type 2 diabetes

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Keywords: Beetroot juice, Beetroot placebo, Cognitive function, Dietary nitrate, Nitrate depleted placebo, Nitrite, Reaction time, Type 2 diabetes

Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo.

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