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      Melhora dos limiares de sensibilidade do campo visual após redução da pressão intra-ocular em pacientes com glaucoma: tratamento cirúrgico vs. clínico Translated title: Improvement in glaucomatous visual field thresholds after reduction of intraocular pressure: clinical vs. surgical treatment

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          Abstract

          OBJETIVO: Comparar a influência do tipo de tratamento em diferentes regiões do campo visual glaucomatoso após redução da pressão intra-ocular (Pio). MÉTODOS: Pacientes com glaucoma que obtiveram redução da Pio de pelo menos 20% em um período de 2 meses foram retrospectivamente selecionados e divididos em 2 grupos: 1) após trabeculectomia; 2) após tratamento clínico. Índices do campo visual e os limiares de sensibilidade (totais, e divididos de acordo com a gravidade no gráfico do "Pattern Deviation") foram anotados imediatamente antes e após a redução da Pio, comparados entre os grupos, e dentro dos mesmos. RESULTADOS: Trinta e um olhos de 22 pacientes foram incluídos no estudo (15 no grupo 1, e 16 no grupo 2). Ambos os grupos demonstraram alta habilidade na melhora de regiões do campo visual após a redução da Pio. Apenas a porcentagem da redução da Pio (52,3±18,9% e 37,8±15,2% para os grupos 1 e 2, respectivamente, p=0,02) e a porcentagem de melhora nos pontos lesados a 0,5% (186,0±213,3% e 30,1±35,2% para os grupos 1 e 2, respectivamente, p=0,02) foram diferentes entre os grupos, porém sem significância após correção do erro alfa. CONCLUSÃO: A redução da Pio acima de 20% pode estar associada à melhora em regiões do campo visual glaucomatoso, independente da modalidade de tratamento.

          Translated abstract

          PURPOSE: To verify the influence of modality of treatment in regions of the glaucomatous visual field after reduction of intraocular pressure (IOP). METHODS: Glaucoma patients that had undergone a reduction of IOP of at least 20% in a period of 2 months were retrospectively selected and divided into 2 groups: 1) after trabeculectomy; 2) after clinical treatment. Visual field global indices and thresholds (average, divided according to the severity based on the Pattern Deviation plot) were compared before and after IOP reduction. RESULTS: Thirty-one eyes of 22 patients were selected (15 in group 1, and 16 in group 2). Both groups showed good ability regarding improvement of different regions of the visual field after IOP reduction. Only the percentage of reduction of IOP (52.3±18.9% and 37.8±15.2% for groups 1 and 2, respectively, p=0.02) and the percentage of improvement in the points damaged at p<0.5% (186.0±213.3% and 30.1±35.2% for groups 1 and 2, respectively, p=0.02) were different, but not statistically significant after alpha error correction between groups. CONCLUSION: The reduction of IOP above 20% may be associated with improvement in regions of the glaucomatous visual field, regardless of treatment modality.

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          Most cited references24

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          The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Collaborative Normal-Tension Glaucoma Study Group.

          In a companion paper, we determined that intraocular pressure is part of the pathogenesis of normal-tension glaucoma by analyzing the effect of a 30% intraocular pressure reduction on the subsequent course of the disease. We report an intent-to-treat analysis of the study data to determine the effectiveness of pressure reduction. One eligible eye of 145 subjects with normal-tension glaucoma was randomized either to no treatment (control) or to a 30% intraocular pressure reduction from baseline. To be eligible for randomization, the normal-tension glaucoma eyes had to show documented progression of field defects or a new disk hemorrhage or had to have field defects that threatened fixation when first presented for the study. Survival analysis compared time to progression of all randomly assigned patients during the course of follow-up from the initial baseline at randomization. In a separate analysis, data of patients developing cataracts were censored at the time that cataract produced 2 lines of Snellen visual acuity loss. Visual field progression occurred at indistinguishable rates in the pressure-lowered (22/66) and the untreated control (31/79) arms of the study (P = .21). In an analysis with data censored when cataract affected visual acuity, visual field progression was significantly more common in the untreated group (21/79) compared with the treated group (8/66). An overall survival analysis showed a survival of 80% in the treated arm and of 60% in the control arm at 3 years, and 80% in the treated arm and 40% in the controls at 5 years. The Kaplan-Meier curves were significantly different (P = .0018). The analyses gave different results because of a higher incidence of cataract in the group that underwent filtration surgery. The favorable effect of intraocular pressure reduction on progression of visual change in normal-tension glaucoma was only found when the impact of cataracts on visual field progression, produced largely by surgery, was removed. Lowering intraocular pressure without producing cataracts is beneficial. Because not all untreated patients progressed, the natural history of normal-tension glaucoma must be considered before embarking on intraocular pressure reduction with therapy apt to exacerbate cataract formation unless normal-tension glaucoma threatens serious visual loss.
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            Primary glaucomas. Gonioscopy, ophthalmoscopy and perimetry.

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              Changes in the nerve fiber layer thickness following a reduction of intraocular pressure after trabeculectomy.

              To assess changes in the nerve fiber layer thickness after trabeculectomy using scanning laser polarimetry.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                abo
                Arquivos Brasileiros de Oftalmologia
                Arq. Bras. Oftalmol.
                Conselho Brasileiro de Oftalmologia (São Paulo )
                1678-2925
                February 2006
                : 69
                : 1
                : 51-55
                Affiliations
                [1 ] Universidade de Campinas Brasil
                [2 ] Universidade Federal de Goiás Brazil
                [3 ] Universidade de São Paulo
                [4 ] Universidade Federal de Goiás Brazil
                Article
                S0004-27492006000100011
                10.1590/S0004-27492006000100011
                3817c40e-8cf4-4eac-9c91-9f392a18140b

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0004-2749&lng=en
                Categories
                OPHTHALMOLOGY

                Ophthalmology & Optometry
                Intraocular pressure,Glaucoma,Perimetry,Tonometry, ocular,Retrospective studies,Treatment outcome,Pressão intra-ocular,Perimetria,Tonometria ocular,Estudos retrospectivos,Resultado de tratamento

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