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      Regulation of neuropeptide gene expression by steroid hormones

      Molecular Neurobiology
      Springer Nature

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          The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis.

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            Steroid receptor regulated transcription of specific genes and gene networks.

            K Yamamoto (1985)
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              A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.

              Nerve growth factor (NGF) is a trophic agent that promotes the outgrowth of nerve fibers from sympathetic and sensory ganglia. The neuronal differentiation stimulated by this hormone was examined in the NGF-responsive cell line PC12. Differential hybridization was used to screen a complementary DNA library constructed from PC12 cells treated with NGF and cycloheximide. One of the complementary DNA clones that was rapidly induced by NGF was found to have a nucleotide sequence that predicts a 54-kilodalton protein with homology to transcriptional regulatory proteins. This clone, NGFI-A, contains three tandemly repeated copies of the 28- to 30-amino acid "zinc finger" domain present in Xenopus laevis TFIIIA and other DNA-binding proteins. It also contains another highly conserved unit of eight amino acids that is repeated at least 11 times. The NGFI-A gene is expressed at relatively high levels in the brain, lung, and superior cervical ganglion of the adult rat.
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                Author and article information

                Journal
                Molecular Neurobiology
                Mol Neurobiol
                Springer Nature
                0893-7648
                1559-1182
                September 1988
                September 1988
                : 2
                : 3
                : 183-200
                Article
                10.1007/BF02935345
                3842c11c-98ed-4553-81a3-6057d031d332
                © 1988
                History

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