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      Comparison of Four Computerized Models to Estimate 24-Hour Growth Hormone Secretion in Girls with Turner’s Syndrome

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          Daily pituitary growth hormone (GH) secretion can be estimated from a 24-hour GH profile by various methods. We have used four methods to assess GH secretion in 36 girls with Turner’s syndrome: the method described by Thompson et al., the Pulsar algorithm combined with the method of Hellman et al. and two deconvolution techniques. The number of detected peaks varied considerably among the methods. The mean ( ± SD) total daily secretion per square meter body surface was 0.53 (0.19) U/m<sup>2</sup>·day by deconvolution, in contrast to 0.31 (0.17) with the Hellman method and 1.06 (0.37) according to Thompson. The differences are explained by different assumptions about the metabolic clearance rate and various methodological aspects. Assuming a degradation rate of 50%, the growth hormone substitution dosage would be 1-2 IU/m<sup>2</sup>· day in GH-deficient children. The usual dosage in girls with Turner’s syndrome is expected to lead to serum GH levels approximately 4 times higher than in the untreated state.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 38
          : 3-4
          : 125-133
          aDivision of Endocrinology, Department of Pediatrics, Wilhelmina Childrens Hospital, State University, Utrecht, The Netherlands; bDivision of Endocrinology and Metabolism, Department of Internal Medicine, and cDepartment of Pharmacology, University of Virginia, Charlottesville, Va., USA
          182527 Horm Res 1992;38:125–133
          © 1992 S. Karger AG, Basel

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          Pages: 9
          Original Paper


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