Comparison of Four Computerized Models to Estimate 24-Hour Growth Hormone Secretion in Girls with Turner’s Syndrome

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Abstract

Daily pituitary growth hormone (GH) secretion can be estimated from a 24-hour GH profile by various methods. We have used four methods to assess GH secretion in 36 girls with Turner’s syndrome: the method described by Thompson et al., the Pulsar algorithm combined with the method of Hellman et al. and two deconvolution techniques. The number of detected peaks varied considerably among the methods. The mean ( ± SD) total daily secretion per square meter body surface was 0.53 (0.19) U/m<sup>2</sup>·day by deconvolution, in contrast to 0.31 (0.17) with the Hellman method and 1.06 (0.37) according to Thompson. The differences are explained by different assumptions about the metabolic clearance rate and various methodological aspects. Assuming a degradation rate of 50%, the growth hormone substitution dosage would be 1-2 IU/m<sup>2</sup>· day in GH-deficient children. The usual dosage in girls with Turner’s syndrome is expected to lead to serum GH levels approximately 4 times higher than in the untreated state.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 03 December 2008

Volume: 38

Issue: 3-4

Pages: 125-133

Affiliations

^aDivision of Endocrinology, Department of Pediatrics, Wilhelmina Childrens Hospital, State University, Utrecht, The Netherlands; ^bDivision of Endocrinology and Metabolism, Department of Internal Medicine, and ^cDepartment of Pharmacology, University of Virginia, Charlottesville, Va., USA

Article

Publisher ID: 182527 Other ID: Horm Res 1992;38:125–133

DOI: 10.1159/000182527

PubMed ID: 1306843

SO-VID: 3865d108-ea4d-4f47-a0c4-4668e7eb8bfc

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 27 January 1992

Date accepted : 27 November 1992

Page count

Pages: 9

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