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      Actions of Parathyroid Hormone in the Cardiovascular System

      Journal of Vascular Research

      S. Karger AG

      Parathyroid hormone, Vascular smooth muscle, Cyclic AMP, Vasorelaxation

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          Recent studies from several laboratories have suggested that the cardiovascular system may be considered a new target organ system for parathyroid hormone (PTH). PTH caused a sharp, dose-dependent reduction in blood pressure of several mammalian models. This hypotensive response was mediated by direct interaction of PTH with the vascular smooth muscle of arteries and resistance vascular beds. Increases in intracellular cyclic AMP concentrations were temporally and quantitatively correlated with smooth muscle relaxation by PTH. Direct (nonreflex) positive inotropic and chronotropic effects have been observed in cardiac tissue after treatment with PTH. Considering these and other observations, a physiological role for PTH as a homeostatic regulator of the cardiovascular system may be speculated.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 24
          : 3
          : 120-124
          Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Tex., USA
          158683 Blood Vessels 1987;24:120–124
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 5
          Neurohumoral Control of Blood Vessel Tone


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