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      Chain Modeling of Molecular Communications for Body Area Network

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          Abstract

          Molecular communications provide an attractive opportunity to precisely regulate biological signaling in nano-medicine applications of body area networks. In this paper, we utilize molecular communication tools to interpret how neural signals are generated in response to external stimuli. First, we propose a chain model of molecular communication system by considering three types of biological signaling through different communication media. Second, communication models of hormonal signaling, Ca 2 + signaling and neural signaling are developed based on existing knowledge. Third, an amplify-and-forward relaying mechanism is proposed to connect different types of signaling. Simulation results demonstrate that the proposed communication system facilitates the information exchange between the neural system and nano-machines, and suggests that proper adjustment can optimize the communication system performance.

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          Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.

          Neurogenesis in the mammalian central nervous system is believed to end in the period just after birth; in the mouse striatum no new neurons are produced after the first few days after birth. In this study, cells isolated from the striatum of the adult mouse brain were induced to proliferate in vitro by epidermal growth factor. The proliferating cells initially expressed nestin, an intermediate filament found in neuroepithelial stem cells, and subsequently developed the morphology and antigenic properties of neurons and astrocytes. Newly generated cells with neuronal morphology were immunoreactive for gamma-aminobutyric acid and substance P, two neurotransmitters of the adult striatum in vivo. Thus, cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.
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            Endocannabinoids mediate neuron-astrocyte communication.

            Cannabinoid receptors play key roles in brain function, and cannabinoid effects in brain physiology and drug-related behavior are thought to be mediated by receptors present in neurons. Neuron-astrocyte communication relies on the expression by astrocytes of neurotransmitter receptors. Yet, the expression of cannabinoid receptors by astrocytes in situ and their involvement in the neuron-astrocyte communication remain largely unknown. We show that hippocampal astrocytes express CB1 receptors that upon activation lead to phospholipase C-dependent Ca2+ mobilization from internal stores. These receptors are activated by endocannabinoids released by neurons, increasing astrocyte Ca2+ levels, which stimulate glutamate release that activates NMDA receptors in pyramidal neurons. These results demonstrate the existence of endocannabinoid-mediated neuron-astrocyte communication, revealing that astrocytes are targets of cannabinoids and might therefore participate in the physiology of cannabinoid-related addiction. They also reveal the existence of an endocannabinoid-glutamate signaling pathway where astrocytes serve as a bridge for nonsynaptic interneuronal communication.
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                Author and article information

                Journal
                Sensors (Basel)
                Sensors (Basel)
                sensors
                Sensors (Basel, Switzerland)
                MDPI
                1424-8220
                18 January 2019
                January 2019
                : 19
                : 2
                : 395
                Affiliations
                [1 ]School of Communication and Information Engineering, Chongqing University of Posts and Telecommunica-Tions, Chongqing 400065, China; S170101193@ 123456stu.cqupt.edu.cn (H.X.); 13028317880@ 123456163.com (L.H.)
                [2 ]Key Laboratory of Optical Communication and Networks in Chongqing, Chongqing 400065, China
                [3 ]Key Laboratory of Ubiquitous Sensing and Networking in Chongqing, Chongqing 400065, China
                Author notes
                [* ]Correspondence: hp6500@ 123456126.com
                Author information
                https://orcid.org/0000-0002-4288-1649
                Article
                sensors-19-00395
                10.3390/s19020395
                6359748
                30669381
                3872a63b-9655-4948-96a7-caf2a1603b3c
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 30 October 2018
                : 15 January 2019
                Categories
                Article

                Biomedical engineering
                molecular communication,hormonal signaling,ca2+ signaling,neural signaling,chain modeling,body area network

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