IL-33/ST2 Pathway as a Rational Therapeutic Target for CNS Diseases.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Interleukin (IL)-33 is a member of the interleukin-1 cytokine family that is produced by many different types of tissues including the central nervous system (CNS). IL-33 mediates its effects via its heterodimeric receptor complex, comprised of ST2 and the IL-1 receptor accessory protein (IL-1RAcp). As a pleiotropic nuclear cytokine, IL-33 is a crucial factor in the development of cardiovascular diseases, allergic diseases, infectious diseases, and autoimmune diseases. Recently, accumulated evidence shows that the IL-33/ST2 axis plays a crucial and diverse role in the pathogenesis of CNS diseases, including neurodegenerative diseases, cerebrovascular diseases, infectious diseases, traumatic CNS injury, chronic pain, etc. In this review, we discuss the recent findings in the cellular signaling of IL-33 and advancement of the role of IL-33 in several CNS diseases, as well as its therapeutic potential for the treatment of those diseases.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Neuroscience

Title: Neuroscience

Publisher: Elsevier BV

ISSN (Electronic): 1873-7544

ISSN (Print): 0306-4522

Publication date (Electronic): Jan 15 2018

Volume: 369

Affiliations

[1 ] Department of Integrative Medicine and Neurobiology, Academy of Integrative Medicine, School of Basic Medical Sciences, Institutes of Brain Science, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, People's Republic of China.

[2 ] Institute of Radiation Medicine, Fudan University, Shanghai 200032, People's Republic of China.

[3 ] Department of Integrative Medicine and Neurobiology, Academy of Integrative Medicine, School of Basic Medical Sciences, Institutes of Brain Science, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, People's Republic of China. Electronic address: wenlimi@fudan.edu.cn.

Article

Publisher Item ID: S0306-4522(17)30822-9

DOI: 10.1016/j.neuroscience.2017.11.028

PubMed ID: 29175156

SO-VID: 3890379f-d876-4ba3-a8ae-9225878035e9

History

Keywords: signaling,interleukin-33,ST2,central nervous system diseases

Data availability:

Keywords: signaling, interleukin-33, ST2, central nervous system diseases

Comments

Comment on this article

scite_

Cited by 20

See all cited by