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      MicroRNA-495 suppresses human renal cell carcinoma malignancy by targeting SATB1.

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          Abstract

          Deregulated expression of miRNAs is related to progression and initiation of human cancers. Although miR-495 has identified in various tumors, its expression and function in renal cell carcinoma (RCC) is still unknown. In this study, we found that the expression of miR-495 was downregulated in RCC cell lines and tissues. Ectopic expression of miR-495 induced G0/G1 phase arrest and suppressed cell proliferation and migration in RCC cell lines. We further validated SATB1 was a direct target of miR-495 in RCC. In addition, re-expression of SATB1 reversed the miR-495-induced inhibition of cell proliferation and migration. These data suggest that miR-495 functions as a tumor suppressor and may be a promising therapeutic target in RCC in the future.

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          Author and article information

          Journal
          Am J Transl Res
          American journal of translational research
          1943-8141
          2015
          : 7
          : 10
          Affiliations
          [1 ] Department of Urology, Haikou Municipal Hospital Haikou, Hainan, 570208, China ; Department of Urology, Renmin Hospital of Wuhan University Wuhan, Hubei, 430060, China.
          [2 ] Department of Urology, Haikou Municipal Hospital Haikou, Hainan, 570208, China.
          [3 ] Department of Urology, Renmin Hospital of Wuhan University Wuhan, Hubei, 430060, China.
          Article
          4656775
          26692942

          Renal cell carcinoma, SATB1, miR-495, microRNAs

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