11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          ELF3, a member of the ETS transcription factor family, has been shown to transactivate the transforming growth factor beta type II receptor (TGF-betaRII) promoter. Previously we showed that Elf3-null mice have a defect in the small intestine caused by a failure of small intestinal epithelial cells to differentiate and that these cells produced significantly lower levels of Tgf-betaRII. To prove that the defect observed in Elf3-null mice resulted from the lack of Elf3-dependent activation of Tgf-betaRII expression, we performed a genetic rescue.

          Related collections

          Author and article information

          Journal
          Gastroenterology
          Gastroenterology
          0016-5085
          0016-5085
          Apr 2007
          : 132
          : 4
          Affiliations
          [1 ] Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.
          Article
          S0016-5085(07)00413-1
          10.1053/j.gastro.2007.02.054
          17408644
          38966e0a-cea8-4b12-8f89-ad80e496b80d
          History

          Comments

          Comment on this article