Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis.

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Abstract

Angiogenesis is disrupted in age-related and postmenopausal osteoporosis. However, the mechanisms of the disorder remain elusive. We confirmed in this study that, in accordance with the decrease of H-type vessels, the proangiogenic potential of bone marrow-derived mesenchymal stem cells (BMSCs) declined during osteoporosis. Screening of the histone acetyltransferase family revealed that GCN5 decreased in BMSCs derived from osteoporotic femur. Further analysis identified that GCN5 plays important roles in regulating the proangiogenic potential of BMSCs. GCN5 promoted BMSC-mediated angiogenesis by enhancing H3K9ac levels on the promoter ofVegfThe decrease of GCN5 in osteoporotic BMSCs led to the decline of proangiogenic capacity. Accordingly, overexpression of GCN5 enhanced the proangiogenic potency of osteoporotic BMSCs. Furthermore, recovering GCN5 expressionin vivoby lentiviral expression vector significantly attenuated the loss of angiogenesis in ovariectomized mouse femurs. Our study results revealed an epigenetic mechanism controlling BMSC-mediated angiogenesis and provided a novel therapeutic target for osteoporosis treatment.-Jing, H., Liao, L., Su, X., Shuai, Y. Zhang, X., Deng, Z., Jin, Y. Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis.

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Journal

Journal ID (iso-abbrev): FASEB J.

Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Publisher: FASEB

ISSN (Electronic): 1530-6860

ISSN (Print): 0892-6638

Publication date (Electronic): October 2017

Volume: 31

Issue: 10

Affiliations

[1 ] State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, China.

[2 ] National Clinical Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, China.

[3 ] Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, China.

[4 ] Xi'an Institute of Tissue Engineering and Regenerative Medicine, Xi'an, China.

[5 ] Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.

[6 ] Department of Prothodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, China.

[7 ] Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi'an, China dengzh@fmmu.edu.cn.

[8 ] State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, China; yanjin@fmmu.edu.cn.

Article

Publisher Item ID: fj.201700118R

DOI: 10.1096/fj.201700118R

PubMed ID: 28642327

SO-VID: 38bc9b53-82ec-4d1c-9561-2ddb7eace7b2

Keywords: mesenchymal stem cell,Kat2a,bone mass loss,vascular formation

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Keywords: mesenchymal stem cell, Kat2a, bone mass loss, vascular formation

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