The microstructure and elevated temperature compressive behavior of Nb-22Ti-16Si-7Cr-3Al-3Ta-2Hf alloys with and without 0.1 at.% Ho were investigated by using scanning electron microscopy, X-ray diffraction, transmission electron microscopy, and compression tests. The results show that the addition of 0.1 at.% Ho to the matrix alloy significantly increases its elevated temperature strength at a higher strain rate, while the strengthening effect becomes weak at a lower strain rate. The elevated temperature compressive deformation behavior of the Ho-doped alloy can be adequately described by the power-law equation. The mechanism of Ho addition on elevated-temperature compressive behavior of the alloy is discussed in the paper.