Effect of Histamine on Basal and TRH/LH-RH-Stimulated PRL and LH Secretion during Different Phases of the Menstrual Cycle in Normal Women

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The neurotransmitter histamine (HA) may participate in the regulation of some pituitary hormones. We, therefore, investigated the effect of HA (50 µg/kg body weight/h, infusion 0–240 min) on basal and thyrotropin-releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) stimulated prolactin (PRL) and LH secretion in 5 normal women during the early follicular and the luteal phases of the same menstrual cycle. HA had no effect on the basal secretion of the two hormones. However, the PRL response to 200 µg TRH during the HA infusion was significantly increased compared to the response to a saline control infusion during the early follicular phase (peak responses were 1,902 ± 398 vs. 1,228 ± 230 µlU/ml, p < 0.025) and during the luteal phase (peak responses were 2,261 ± 335 vs. 1,647 ± 245 µlU/ml, p < 0.05). HA potentiated the LH response to 100 µg LH-RH during the early follicular phase (peak responses were 37.1 ± 4.9 vs. 26.9 ± 4.5 mlU/ml, p < 0.05) and during the luteal phase (peak responses were 79.3 ± 22.5 vs. 50.7 ± 11.4 mlU/ml, p < 0.025). We, therefore, found HA to have a potentiating effect on TRH/LH-RH-stimulated PRL and LH secretion in women. The results are similar to our previous findings in men, although the potentiating effects of HA were higher in women.

Related collections

Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1985

Publication date (Print): 1985

Publication date (Electronic): 28 March 2008

Volume: 41

Issue: 4

Pages: 337-341

Affiliations

Department of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, and Hormone Department, Statens Seruminstitut, Copenhagen, Denmark

Article

Publisher ID: 124198 Other ID: Neuroendocrinology 1985;41:337–341

DOI: 10.1159/000124198

PubMed ID: 3930987

SO-VID: 38feacc3-3a2d-4190-a443-da02f835b2aa

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 03 July 1984

Date accepted : 12 December 1984

Page count

Pages: 5

Comments

Comment on this article

scite_