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      Synthetic biology in mammalian cells: next generation research tools and therapeutics.

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          Abstract

          Recent progress in DNA manipulation and gene circuit engineering has greatly improved our ability to programme and probe mammalian cell behaviour. These advances have led to a new generation of synthetic biology research tools and potential therapeutic applications. Programmable DNA-binding domains and RNA regulators are leading to unprecedented control of gene expression and elucidation of gene function. Rebuilding complex biological circuits such as T cell receptor signalling in isolation from their natural context has deepened our understanding of network motifs and signalling pathways. Synthetic biology is also leading to innovative therapeutic interventions based on cell-based therapies, protein drugs, vaccines and gene therapies.

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          Author and article information

          Journal
          Nat. Rev. Mol. Cell Biol.
          Nature reviews. Molecular cell biology
          Springer Nature
          1471-0080
          1471-0072
          Feb 2014
          : 15
          : 2
          Affiliations
          [1 ] Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
          [2 ] 1] Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
          Article
          nrm3738 NIHMS574960
          10.1038/nrm3738
          4032074
          24434884
          390009fe-d43f-40c6-b3c6-48ae6621c06b
          History

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