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      Estimation of Glomerular Filtration Rate by Serum Creatinine and Serum β 2-Microglobulin

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      Author(s): ,
      Publication date (Electronic):
      Journal: Nephron
      Publisher: S. Karger AG
      Keywords: Glomerular filtration rate, Serum creatinine, Serum β2-microglobulin

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          Abstract

          <sup>51</sup>Cr-EDTA clearance, serum β<sub>2</sub>-microglobulin and serum creatinine were measured simultaneously on 271 occasions in 114 patients. Serum β<sub>2</sub>-microglobulin was more sensitive than serum creatinine for detection of changes of glomerular filtration rate (GFR) and for detection of a moderately reduced GFR. However, serum β<sub>2</sub>-microglobulin also had severe limitations when used to estimate GFR. The serum levels of the protein varied considerably in patients with similar GFR, probably due to different rates of synthesis of β<sub>2</sub>-microglobulin.

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          Author and article information

          Journal
          Journal ID (publisher-id): NEF
          Journal ID (nlm-ta): Nephron
          Journal ID (doi): 10.1159/issn.1660-8151
          Title: Nephron
          Publisher: S. Karger AG
          ISSN (Print): 1660-8151
          ISSN (Electronic): 2235-3186
          Publication date Subscription-year: 1981
          Publication date (Print): 1981
          Publication date (Electronic): 02 December 2008
          Volume: 28
          Issue: 4
          Pages: 196-199
          Affiliations
          University of Göteborg, Göteborg (Sweden)
          Article
          Publisher ID: 182197 Other ID: Nephron 1981;28:196–199
          DOI: 10.1159/000182197
          PubMed ID: 6170902
          SO-VID: 3918d85e-b6e1-4246-90c1-eb9dc5a9dce9
          Copyright © © 1981 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date accepted : 03 September 1980
          Page count
          Pages: 4
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
          Keywords: Glomerular filtration rate,Serum β2-microglobulin,Serum creatinine
          Data availability:
          ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
          Keywords: Glomerular filtration rate, Serum β2-microglobulin, Serum creatinine

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