Comparison of Renal Effects of Creatinine, Creatol and Methylguanidine in Rats with Adenine-lnduced Chronic Renal Failure

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Abstract

Creatinine (Cr), creatol and methylguanidine (MG), which accumulate in the body with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine was given to rats for 20 days to induce renal failure. Then each of the test substances was administered intraperitoneally, and renal function of the rats was determined. The changes in glomerular filtration rate, renal plasma flow and renal blood flow after administration of Cr were only slight in comparison with those of the control group. Creatol or MG administration induced a significant decrease in renal function. In addition, the level of MG in serum, liver and kidney was extraordinarily high in rats given creatol or MG. The toxic effects are discussed on the basis of these results.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1993

Publication date (Print): 1993

Publication date (Electronic): 12 December 2008

Volume: 64

Issue: 3

Pages: 424-428

Affiliations

^aResearch Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama; ^bInstitute of Bio-Active Science, Nippon Zoki Pharmaceutical Co., Kato-gun, Hyogo, Japan

Article

Publisher ID: 187365 Other ID: Nephron 1993;64:424–428

DOI: 10.1159/000187365

PubMed ID: 8341388

SO-VID: 392d8640-51b6-4cad-b091-31735421da37

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Comparison of Renal Effects of Creatinine, Creatol and Methylguanidine in Rats with Adenine-lnduced Chronic Renal Failure

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Karger: Nephrology

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