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      Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria : A comprehensive pro-poor health policy and strategy for the developing world

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          Abstract

          Hotez et al. argue that achieving success in the global fight against HIV/AIDS, tuberculosis, and malaria may well require a concurrent attack on the neglected tropical diseases.

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          Most cited references131

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          Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis.

          Schistosomiasis is one of the world's most prevalent infections, yet its effect on the global burden of disease is controversial. Published disability-adjusted life-year (DALY) estimates suggest that the average effect of schistosome infection is quite small, although this is disputed. To develop an evidenced-based reassessment of schistosomiasis-related disability, we did a systematic review of data on disability-associated outcomes for all forms of schistosomiasis. We did structured searches using EMBASE, PUBMED, and Cochrane electronic databases. Published bibliographies were manually searched, and unpublished studies were obtained by contacting research groups. Reports were reviewed and abstracted independently by two trained readers. All randomised and observational studies of schistosomiasis morbidity were eligible for inclusion. We calculated pooled estimates of reported disability-related effects using weighted odds ratios for categorical outcomes and standardised mean differences for continuous data. 482 published or unpublished reports (March, 1921, to July, 2002) were screened. Of 135 selected for inclusion, 51 provided data for performance-related symptoms, whereas 109 reported observed measures of disability-linked morbidities. Schistosomiasis was significantly associated with anaemia, chronic pain, diarrhoea, exercise intolerance, and undernutrition. By contrast with WHO estimates of 0.5% disability weight assigned to schistosomiasis, 2-15% disability seems evident in different functional domains of a person with schistosomiasis. This raised estimate, if confirmed in formal patient-preference studies, indicates a need to reassess our priorities for treating this silent pandemic of schistosomiasis.
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            Soil-transmitted helminth infections: updating the global picture.

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              “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor

              Controlling seven tropical infections in Africa would cost just 40 cents per person per year, and would permanently benefit hundreds of millions of people.
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                Author and article information

                Journal
                PLoS Med
                pmed
                PLoS Medicine
                Public Library of Science (San Francisco, USA )
                1549-1277
                1549-1676
                May 2006
                31 January 2006
                : 3
                : 5
                : e102
                Author notes

                Competing Interests: Please see Acknowledgments.

                Peter J. Hotez is Professor and Chair of the Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, District of Columbia, United States of America, and Principal Scientist of the Human Hookworm Vaccine Initiative, Albert B. Sabin Vaccine Institute, Washington, District of Columbia, United States of America. David H. Molyneux is Professor of Tropical Health Sciences and Director of the Lymphatic Filariasis Support Centre, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. Alan Fenwick is Professor of Tropical Parasitology, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom, and Director of the Schistosomiasis Control Initiative, London, United Kingdom. Eric Ottesen is Research Professor of International Health, Rollins School of Public Health, Emory University, Georgia, United States of America, and Director of the Lymphatic Filariasis Support Center, The Task Force for Child Survival and Development, Atlanta, Georgia, United States of America. Sonia Ehrlich Sachs is Coordinator of public health programs, Millennium Village Project of the Earth Institute, Columbia University, New York, New York, United States of America. Jeffrey D. Sachs is Quetelet Professor of Sustainable Development and Director of the Earth Institute, Columbia University, New York, New York, United States of America.

                * To whom correspondence should be addressed. E-mail: mtmpjh@ 123456gwumc.edu
                Article
                10.1371/journal.pmed.0030102
                1351920
                16435908
                3937542f-bf60-4bd9-b9c1-94c372732f69
                Copyright: © 2006 Hotez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
                History
                Categories
                Neglected Diseases
                Infectious Diseases
                Epidemiology/Public Health
                Health Economics
                Health Policy
                Hematology
                HIV/AIDS
                Pediatrics
                Infectious Diseases
                HIV Infection/AIDS
                Malaria
                Tuberculosis
                Medicine in Developing Countries

                Medicine
                Medicine

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