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The ligand-loss photochemistry of cis-[Ru(bpy)(2)(NH(3))(2)](2+) (bpy = 2,2'-bipyridine)
was investigated in water and in the presence of added ligands such as bipyridine
and chloride. Irradiation of the complex results in the covalent binding to 9-methyl-
and 9-ethylguanine, as well as to single-stranded and double-stranded DNA. This photoinduced
DNA binding is not observed for the control complex [Ru(bpy)(2)(en)](2+) (en = ethylenediamine)
under similar irradiation conditions. The results presented here show that octahedral
Ru(II) complexes with photolabile ligands may prove useful as photoactivated cisplatin