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      Photoinitiated DNA Binding bycis-[Ru(bpy)2(NH3)2]2+

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      Inorganic Chemistry

      American Chemical Society (ACS)

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          Abstract

          The ligand-loss photochemistry of cis-[Ru(bpy)(2)(NH(3))(2)](2+) (bpy = 2,2'-bipyridine) was investigated in water and in the presence of added ligands such as bipyridine and chloride. Irradiation of the complex results in the covalent binding to 9-methyl- and 9-ethylguanine, as well as to single-stranded and double-stranded DNA. This photoinduced DNA binding is not observed for the control complex [Ru(bpy)(2)(en)](2+) (en = ethylenediamine) under similar irradiation conditions. The results presented here show that octahedral Ru(II) complexes with photolabile ligands may prove useful as photoactivated cisplatin analogs.

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          Author and article information

          Journal
          Inorganic Chemistry
          Inorg. Chem.
          American Chemical Society (ACS)
          0020-1669
          1520-510X
          November 2004
          November 2004
          : 43
          : 23
          : 7260-7262
          Article
          10.1021/ic049075k
          15530069
          © 2004
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