Effects of Nifedipine, Acebutolol, and Their Association on Exercise Tolerance in Patients with Effort Angina

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Abstract

The action of nifedipine (N), acebutolol (A), and their association (A+N) was studied in 16 patients suffering from effort angina with documented coronary artery disease. The therapeutic action was valued by bicycle effort stress test after oral administration of medications in comparison with placebo (P), following a double-blind random sequence of treatments. Working capacity significantly increased after A (507 ± 450 mkp, p < 0.05), after N (1,140 ± 767 mkp, p < 0.001), and after A+N (1,198 ± 644 mkp, p < 0.01). The increments of work after P administration were not significant. Moreover, fatigue instead of angina appeared as a stopping criterion in 8 patients after A+N, and in only 1 patient after P, A, and N.

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Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISBN: 978-3-8055-3437-6

ISBN: 978-3-318-00026-9

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1981

Publication date (Print): 1981

Publication date (Electronic): 07 November 2008

Volume: 68

Issue: Suppl 2

Pages: 194-199

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Centro A, De Gasperis, Ospedale Niguarda Cà Granda, Milano, Italia

Article

Publisher ID: 173337 Other ID: Cardiology 1981;68:194–199

DOI: 10.1159/000173337

SO-VID: 395da6ae-7982-4288-8b60-b04887c2fcf4

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Effects of Nifedipine, Acebutolol, and Their Association on Exercise Tolerance in Patients with Effort Angina

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Karger: Cardiovascular System

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