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      Role of fractional flow reserve in guiding intervention for borderline coronary lesions

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          Abstract

          Objective: This study investigated the clinical efficacy and value of fractional flow reserve (FFR) in guiding the treatment of borderline coronary lesions.

          Methods: Forty-three patients with borderline coronary lesions, as demonstrated by coronary angiography, and who had FFR measurements were selected. The patients were grouped according to FFR values. All patients were evaluated 6 months after surgery to record major adverse cardiac events (MACE [sudden cardiac death, non-fatal myocardial infarction, or revascularization]) and recurrence of angina pectoris.

          Results: After the 6-month follow-up, no sudden cardiac deaths or myocardial infarctions occurred in either group, and there were no statistically significant differences ( P>0.05). Inter-group comparisons showed that in the groups with a FFR<0.75, the recurrence rate of angina pectoris in the PCI group was significantly lower than the drug therapy group (0.08% vs. 0.27%, P<0.05). In contrast, the recurrence rate of angina pectoris in the PCI group among the groups with a FFR<0.75 revealed no statistical significance when compared to the groups with a FFR≥0.75 (0.08% vs. 0.05%, P>0.05). The recurrence rate of angina pectoris in the simple drug therapy group among the groups with a FFR<0.75 was higher than the same groups with a FFR≥0.75 (0.27% vs. 0.05%, P<0.05).

          Conclusion: When coronary intervention is used to treat borderline lesions, guiding interventional therapy with measurement of FFR does not increase the incidence of adverse cardiovascular events in the short term and can better guide PCI therapy.

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          Most cited references 23

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          Fractional flow reserve - The influence of the collateral circulation

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            A prospective natural-history study of coronary atherosclerosis

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              Current concepts of integrated coronary physiology in the catheterization laboratory

               MJ Kern,  H Samady (2010)
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                Author and article information

                Journal
                FMCH
                Family Medicine and Community Health
                FMCH
                Family Medicine and Community Health & American Chinese Medical Education Association (USA )
                xxx-xxx
                2305-6983
                September 2014
                December 2014
                : 2
                : 3
                : 18-25
                Affiliations
                1Affiliated Hospital of Traditional Chinese Medicine, XinJiang Medical University, XinJiang 830000, China
                Author notes
                CORRESPONDING AUTHOR: Xuekun Shi, Affiliated Hospital of Traditional Chinese Medicine, XinJiang Medical University, XinJiang 830000, China, E-mail: ruick0709@ 123456163.com
                Article
                fmch20140117
                10.15212/FMCH.2014.0117
                Copyright © 2014 Family Medicine and Community Health

                This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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                Self URI (journal page): http://fmch-journal.org/
                Categories
                Original Research

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