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      Reproducibility of Vitreous Fluorophotometry in Patients with Type 1 Diabetes Mellitus

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          We assessed the day-to-day reproducible of vitreous fluorophotometry in 7 type 1 diabetic patients and in 1 healthy control subject. The coefficient of variation for duplicate measurements was 33.7,40.3 and 23.6%, for the right eyes, the left eyes and mean values of both eyes, respectively. Assessment of reproducibility in 1 healthy subject, measured 4 times, resulted in coefficients of variation of about 60%. These values are somewhat worse than those obtained by others in healthy subjects. Since technical problems do not seem to play a significant role in this regard, our reproducibility results reflect the true biological variability of the permeability of the blood-retina barrier assessed by vitreous fluorophotometry in diabetic patients. This variability is substantial. Therefore, we conclude that this method is not precise enough to be used in intervention studies with a limited number of subjects.

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          Author and article information

          S. Karger AG
          01 April 2010
          : 211
          : 4
          : 209-213
          aSt. Lucas Ziekenhuis, Winschoten, and Departments of bGeneral Internal Medicine and cOphthalmology, University Hospital Groningen, The Netherlands
          310791 Ophthalmologica 1997;211:209–213
          © 1997 S. Karger AG, Basel

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